I earned a B.S. in Biology from the University of Notre Dame, and subsequently completed a Ph.D. in Genetics from Harvard University in the laboratory of Norbert Perrimon, where my graduate work consisted of a molecular and phenotypic analysis of two genes involved in segmentation of the Drosophila embryo. After a postdoctoral interlude in the laboratory of Armen Manoukian at the Ontario Cancer Institute studying the role of heparin sulfate proteoglycans in embryonic development in Drosophila, I returned to the Perrimon lab. I am currently working on projects to determine the functions of miRNAs during development, and to generate new tools for lineage analysis.
I graduated from Penn State with a degree in communications. Before joining the Perrimon Lab, I worked in the Harvard T.H. Chan School of Public Health in Dr. Andrea Baccarelli’s Laboratory of Human Environmental Epigenomics.
Before attending graduate school, I conducted research as an undergraduate studying the evolution of floral architecture, and later as a technician studying the developmental genetics of the zebrafish pancreas. For my PhD, I worked with Iswar Hariharan at the University of California – Berkeley, where I used genetics and cell biology to investigate the molecular mechanisms of tissue growth in Drosophila. In the Perrimon lab, I am interested in discovering fundamental signals used by animal cells to communicate. In particular, I am developing methods to study the biological functions of an extraordinary class of intercellular messages — those that transfer directly into the interior of recipient cells. While not in lab, I enjoy biking and hiking around Boston.
I received my Ph.D. from the University of Rochester in the laboratory of Dr. Dirk Bohmann. My doctoral studies were focused towards uncovering novel mechanisms of regulation of Nrf2 signaling and studying their effect on oxidative stress response. In the Perrimon lab I am interested to study how different organs communicate with each other to maintain metabolic homeostasis.
I received my Ph.D. from the University of Texas Health Science Center at Houston. During my graduate studies in Dr. Georg Halder's lab at MD Anderson cancer center, I investigated the role of apical-basal polarity determinants in growth control. Currently, I am interested in using genetic approaches and genomic tools to study the cellular and molecular mechanisms underlying the aging process.
I received my Ph.D. from the University of Cambridge in the lab of Phil Jones (MRC Cancer Cell Unit) working on stem/progenitor cell fate in homeostatic mammalian skin and esophagus. I then switched to Drosophila for postdoctoral work on live imaging of collective cell migration (with Pernille Rorth, IMCB, Singapore) and temporal regulation of stem cell fate in neural stem cells (with Andrea Brand, Gurdon Institute, Cambridge, UK). In the Perrimon lab my focus is on signaling crosstalk in the homeostasis and regeneration of the adult midgut epithelium. In particular I am combining genome-wide approaches with live imaging to better understand the regulation of stem cell fate by multiple pathways.
As an undergraduate, I studied developmental biology with Scott Gilbert at Swarthmore College. I then worked as a technician in Doug Emlen's lab at the University of Montana, studying the development of beetle horns, and in 2014 I received my PhD from Harvard University, working in Cassandra Extavour's lab on the embryonic specification of germ cells. In the Perrimon lab, I am studying long-range regulation of germline stem cell proliferation, and I am also interested in developing new tools for manipulating gene expression.
I received my PhD from the University of Minnesota in Dr. Michael O’Connor's lab. I worked on a variety of topics in the O’Connor lab including regulation of developmental timing, metabolic regulation by TGF-beta signaling and cell-type specific RNA tagging. In the Perrimon lab my focus is on the endocrine role of the muscle in regulating metabolism and physiology. In particular I am interested in studying activity induced myokines that signal to distant tissues like the FB and regulates homeostasis.
I obtained my PhD in Denise Montell's group at Department of Biological Chemistry, Johns Hopkins University in 2012. My graduate work used optogenetic and live-cell imaging techniques to study in vivo collective cell migration and tissue morphogenesis. My postdoc research in the Perrimon lab focuses on the mutual recognition and communication between different cell populations and their impacts on organ development and regeneration.
I received my Ph.D from the University of Texas Southwestern Medical Center at Dallas, 2013. During my graduate studies in Dr. Jonathan Terman lab, I explored the cellular and biochemical means through which one of the largest families of axon guidance cues, the Semaphorins, control cell movement. Working on a family of unusual proteins called MICALs, which associated with Semaphorin receptor Plexin, I found that Mical is a novel actin disassembly factor that uses its redox enzymatic activity to oxidize a specific methionine residue of the actin filaments; therefore, disrupts the actin polymerization. Currently, I am interested in using genetic approaches to study the molecular mechanisms of aging.
I received my Ph.D. from the University of Nice-Sophia Antipolis in France in Dr. Stephane Noselli's lab, where I studied the diet-dependent control of oogenesis in Drosophila. I am now combining genetic screens and metabolomics with dietary supplementation approaches to understand how variations in diet rewires the metabolic networks to optimize nutrient utilization during development.
I obtained my Ph.D. in Biochemistry and Molecular biology from Northwestern University where I studied the mechanism of RNA interference in the laboratory of Dr. Richard Carthew. My research in the Perrimon Lab is focused on understanding the transcriptional regulation of miRNAs and their biological functions in the context of cell growth and survival.
As an undergraduate at Wuhan University, I studied protein glycosylation by mass spectrometry in the laboratory of Dr. Lin Guo. I received my Ph.D. in genetics, development and disease program at University of Texas Southwestern Medical Center, where I studied transcriptional regulations of intestinal stem cell identity in Drosophila by genetics and genomics with Dr. Huaqi Jiang. My research in the Perrimon Lab focuses on developing new tools to study inter-organ communication.
I received my Ph.D. from the Russian State Medical University (Moscow). Under the exchange program I performed my graduate studies at Dr. Henske’s laboratory in Fox Chase Cancer Center (Philadelphia) and Brigham and Women’s Hospital/Harvard Medical School (Boston). During my graduate studies I was investigating the role of autophagy and altered metabolism in the pathogenesis and treatment of Tuberous Sclerosis and Lymphangioleiomyomatosis. Currently, I am interested in the using tumor models in Drosophilafor the search of new modulators of tumorigenesis. I am also interested in the studying the metabolic alterations and their potential targeting during aging.