Enzo Mameli, Ph.D.
Before graduate school, I studied Biotechnologies and Medical Biotechnologies at the University of Sassari and University of Rome “La Sapienza”, Italy.
I did my PhD studies under the mentorship of Dr. Flaminia Catteruccia, initially at the University of Perugia, Italy, and later on at Harvard T.H. Chan School of Public Health, as part of a visitor exchange program. During this period, I investigated the role of male accessory gland-specific transcription factors regulating reproductive homeostasis and performed mass spectrometry studies to determine the composition of the male “ejaculome” in the malaria mosquito Anopheles gambiae. For a short period after my doctoral studies, I continued my postdoctoral training in the same laboratory following up some research lines generated from my previous work. After this experience I visited Dr. Tonya Colpitts’s lab at Boston University / NEIDL where I familiarized with arboviral infections in insect cell lines and adult Aedes mosquitoes.
In the Perrimon lab I am optimizing the existing Drosophila CRISPR-based wide-genome screening technology for direct application in mosquito cell lines; our principal aim is to use this genetic tool to unravel the complicated interactions between vectors and arboviruses, and decipher how the nature of these relationships shape these viruses epidemiology worldwide.