I received my Ph.D. in Molecular and Human Genetics under the supervision of Prof. Ashim Mukherjee from Banaras Hindu University, Varanasi, India. As a graduate student I got an opportunity to work on identification and functional characterization of novel interactors of Notch Signaling pathway in Drosophila melanogaster. As a post-doc in the Perrimon lab, I am interested to explore the mechanism of regulation of different signaling components and their cross-talk during development using molecular genetic approaches in Drosophila.
I earned my Ph.D. from the Max Delbrueck Center for Molecular Medicine, Berlin, Germany, where I studied the role of the microRNA pathway in maintaining the function of pancreatic beta cells. Using several cellular and mouse model systems, I could demonstrate how Argonaute2 regulates secretome and proliferation of the beta cells. As a postdoc in the Perrimon Lab, I am integrating emerging technologies including CRISPR and single cell transcriptomics to delineate mechanisms governing blood cell homeostasis and characterize novel blood cell populations in Drosophila. In the future, I aim to focus on immunometabolism by understanding the dynamics of hematopoiesis during disease states such as Diabetes and Cancer. My other activities include running 10Ks, besides just running gels in the lab.
I am intrigued by the dynamic regulation of subcellular compartments in eukaryotic cells. I got my Ph.D. from Tony Bretscher’s lab at Cornell University through studies of the dynamic spatial and temporal regulation of a key cytoskeletal protein, ezrin, by its kinase. Manipulating the dynamics led to the reversible, selective loss of a subcellular structure called microvilli. In the Perrimon Lab, I hope to use proteomics and functional genomics to obtain a detailed parts list for many more subcellular components with the goal of gaining broad insight into their formation, the regulation of their abundance and morphology, their evolution, and their involvement in tissue-specific cell functions.
I received my Ph.D. in Prof. Qi Zhou's lab at the Institute of Zoology, Chinese Academy of Sciences in 2017. My graduate work focused on pluripotency regulation and ploidy maintenance of embryonic stem cells. In Prof. Perrimon's lab, I am taking genome wide genetic screening to study molecular sensing and homeostatic maintaining in the negative entropy system of life.
I received my Ph.D. from Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences under the supervision by Dr. Yongping Huang and Dr. Anjiang Tan, where I studied the sex determination and spider silk production by using silkworm as a model. In the Perrimon Lab, I want to establish new immunological methods to dissect the inter-organ communication network with high sensitivity.