Correspondence

2019
Droujinine IA, Perrimon N. The Multidimensional Organization of Interorgan Communication Networks. Dev Cell. 2019;50 (4) :395-396. Abstract
Secreted molecules coordinate organ function. In a recent issue of Cell, Hudry et al. (2019) uncover a Drosophila testis-midgut interaction via cytokine and citrate signaling that regulates intestinal metabolism, spermatogenesis, and food intake. This impressive study is a striking example of the role of spatial organization in sex-specific interorgan communication.
2019_DevCell_Droujinine.pdf
2017
Anderson WP, Anderson WP. Data management: A global coalition to sustain core data. Nature. 2017;543 (7644) :179. Abstract
Collaborators: Cochrane G, Di Francesco V, Donohue T, Durinx C, Game A, Green E, Gojobori T, Goodhand P, Hamosh A, Hermjakob H, Kanehisa M, Kiley R, McEntyre J, McKibbin R, Miyano S, Pauly B, Perrimon N, Ragan MA, Richards G, Teo YY, Westerfield M, Westhof E, Lasko PF.
2017_Nature_Anderson.pdf
Teleman AA, Perrimon N. Open questions: completing the parts list and finding the integrating signals. BMC Biol. 2017;15 (1) :47. Abstract
One of the great revelations of post-genomic biology has been the extent to which essential functions and mechanisms are conserved across vast phylogenetic distances. Because of this, we can look to the fruit fly for answers to pressing open questions on the unknown functions of genes and the mechanisms of their physiological integration.
2017_BMC Bio_Teleman.pdf
2016
Perrimon N, Bonini NM, Dhillon P. Fruit flies on the front line: the translational impact of Drosophila. Dis Model Mech. 2016;9 (3) :229-31. Abstract

Drosophila melanogaster has been adopted as one of the most-used model systems since it was first introduced by Thomas Morgan for the study of heredity in the early 20th century. Its experimental tractability and similarity of its biological pathways to those of humans have placed the model at the forefront of research into human development and disease. With the ongoing accumulation of genetic tools and assays, the fly community has at its fingertips the resources to generate diverse Drosophila disease models for the study of genes and pathways involved in a wide range of disorders. In recent years, the fly has also been used successfully for drug screening. In this Editorial, we introduce a Special Collection of reviews, interviews and original research articles that highlight some of the many ways that Drosophila has made, and continues to make, an impact on basic biological insights and translational science.

2016_Dis Mod Mech_Perrimon.pdf
2015
Akbari OS, Bellen HJ, Bier E, Bullock SL, Burt A, Church GM, et al. BIOSAFETY. Safeguarding gene drive experiments in the laboratory. Science. 2015;349 (6251) :927-9. 2015_Science_Akbari.pdf
2011
Perrimon N. Deciphering gene expression patterns (Paper Pick). Developmental Cell. 2011;21 :e1. 2011_Dev Cell_Perrimon.pdf
Friedman AA, Perrimon N. Science Signaling Podcast: 25 October 2011 [Internet]. ScienceMag.org. 2011; Publisher's VersionAbstract

This Podcast features a conversation with authors of a Research Resource published in the 25 October 2011 issue of Science Signaling. Although the extracellular signal–regulated kinase (ERK) pathway has been extensively studied, our understanding of all the regulatory interactions that modulate signaling is by no means complete. Adam Friedman and Norbert Perrimon discuss their group’s strategy of combining functional and genomics approaches to identify common and specific regulators of ERK signaling in the fruit fly Drosophila melanogaster. The ERK pathway plays an important role in normal developmental and physiological contexts as well as in disease states, such as tumorigenesis.

2011_Sci Sig_Friedman (Audio).mp3 2011_Sci Sig_Friedman (Transcript).pdf
2009
Perrimon N. Building on the Shoulders of Giants (Journal Club). Nature Reviews Molecular and Cell Biology. 2009;10 :144. 2009_Nat Rev MCB_Perrimon.pdf
2008
Perrimon N. Journal Club. Nature. 2008;452 :669. 2008_Nature_Perrimon.pdf
2005
Perrimon N. Q & A - Norbert Perrimon. Current Biology. 2005;15 (13) :R481-R482. 2005_Curr Bio_Perrimon.pdf
2004
Perrimon N, Häcker U. Wingless, hedgehog and heparan sulfate proteoglycans. Development. 2004;131 (11) :2509-11; author reply 2511-3. 2004_Dev_Hacker.pdf
2001
Bilder D, Birnbaum D, Borg J-P, Huibregtse J, Kennedy M, Labouesse M, et al. Response to "Problems with LAP nomenclature.". Nat Cell Biol. 2001;3 (4) :E90. 2001_Nat Cell Bio_Bilder.pdf
2000
Bilder D, Birnbaum D, Borg JP, Bryant P, Huigbretse J, Jansen E, et al. Collective nomenclature for LAP proteins. Nat Cell Biol. 2000;2 (7) :E114. 2000_Nat Cell Bio_Bilder.pdf