Ruei-Jiun Hung, Ph.D.
I received my Ph.D from the University of Texas Southwestern Medical Center at Dallas, 2013. During my graduate studies in Dr. Jonathan Terman lab, I explored the cellular and biochemical means through which one of the largest families of axon guidance cues, the Semaphorins, control cell movement. Working on a family of unusual proteins called MICALs, which associated with Semaphorin receptor Plexin, I found that Mical is a novel actin disassembly factor that uses its redox enzymatic activity to oxidize a specific methionine residue of the actin filaments; therefore, disrupts the actin polymerization. Currently, I am interested in using genetic approaches to study the molecular mechanisms of aging.