Synthetic Notch receptors and their applications to study cell-cell contacts in vivo
Publication information:
He L, Norbert P. Synthetic Notch receptors and their applications to study cell-cell contacts in vivo.
Developmental Cell. 2023;58(3):171–173.
Abstract
Physical cell-cell interaction is a fundamental mechanism that controls the development and physiology of multicellular organisms. However, methods to study cell contact within complex tissues are limited. In a recent issue of Science, Zhang et al. developed synthetic Notch (synNotch)-based tools that can monitor and trace cell-cell contacts in mammals.