Citation:
Kwon YV, Zhao B, Xu C, Lee J, Chen C-L, Vinayagam A, et al. The role of translationally controlled tumor protein in proliferation of intestinal stem cells. Proc Natl Acad Sci U S A. 2019;
 | 2019_PNAS_Kwon.pdf | 1.83 MB |
| Supplement.pdf | 9.5 MB |
Date Published:
2019 Dec 16Abstract:
Translationally controlled tumor protein (TCTP) is a highly conserved protein functioning in multiple cellular processes, ranging from growth to immune responses. To explore the role of TCTP in tissue maintenance and regeneration, we employed the adult midgut, where multiple signaling pathways interact to precisely regulate stem cell division for tissue homeostasis. Tctp levels were significantly increased in stem cells and enteroblasts upon tissue damage or activation of the Hippo pathway that promotes regeneration of intestinal epithelium. Stem cells with reduced Tctp levels failed to proliferate during normal tissue homeostasis and regeneration. Mechanistically, Tctp forms a complex with multiple proteins involved in translation and genetically interacts with ribosomal subunits. In addition, Tctp increases both Akt1 protein abundance and phosphorylation in vivo. Altogether, Tctp regulates stem cell proliferation by interacting with key growth regulatory signaling pathways and the translation process in vivo.See also: Research Article
