Fringe connection

Selva EM, Hong K, Baeg GH, Beverley SM, Turco SJ, Perrimon N, et al. Dual role of the fringe connection gene in both heparan sulphate and fringe-dependent signalling events. Nat Cell Biol. 2001;3 (9) :809-15. Abstract

The precise regulation of growth factor signalling is crucial to the molecular control of development in Drosophila. Post-translational modification of signalling molecules is one of the mechanisms that modulate developmental signalling specificity. We describe a new gene, fringe connection (frc), that encodes a nucleotide-sugar transporter that transfers UDP-glucuronic acid, UDP-N-acetylglucosamine and possibly UDP-xylose from the cytoplasm into the lumen of the endoplasmic reticulum/Golgi. Embryos with the frc mutation display defects in Wingless, Hedgehog and fibroblast growth factor signalling. Clonal analysis shows that fringe-dependent Notch signalling is disrupted in frc mutant tissue.

2001_Nat Cell Bio_Selva.pdf
Goode S, Perrimon N. Brainiac and Fringe are pioneer proteins that impart specificity to Notch signals during Drosophila development. In: Symposia on Quantitative Biology. Cold Spring Harbor; 1998. p. 177-184. 1997_CSHQB_Goode.pdf