%0 Journal Article %J Nat Cell Biol %D 2001 %T Dual role of the fringe connection gene in both heparan sulphate and fringe-dependent signalling events. %A Selva, E M %A Hong, K %A Baeg, G H %A Beverley, S M %A Turco, S J %A Perrimon, N %A Häcker, U %K Amino Acid Sequence %K Animals %K Cytoplasm %K Drosophila melanogaster %K Drosophila Proteins %K Endoplasmic Reticulum %K Glycosyltransferases %K Golgi Apparatus %K Heparitin Sulfate %K Humans %K Molecular Sequence Data %K Morphogenesis %K N-Acetylglucosaminyltransferases %K Phenotype %K Sequence Alignment %K Sequence Homology, Amino Acid %K Signal Transduction %K Uridine Diphosphate Glucuronic Acid %K Uridine Diphosphate N-Acetylglucosamine %K Uridine Diphosphate Xylose %K Wings, Animal %X

The precise regulation of growth factor signalling is crucial to the molecular control of development in Drosophila. Post-translational modification of signalling molecules is one of the mechanisms that modulate developmental signalling specificity. We describe a new gene, fringe connection (frc), that encodes a nucleotide-sugar transporter that transfers UDP-glucuronic acid, UDP-N-acetylglucosamine and possibly UDP-xylose from the cytoplasm into the lumen of the endoplasmic reticulum/Golgi. Embryos with the frc mutation display defects in Wingless, Hedgehog and fibroblast growth factor signalling. Clonal analysis shows that fringe-dependent Notch signalling is disrupted in frc mutant tissue.

%B Nat Cell Biol %V 3 %P 809-15 %8 2001 Sep %G eng %N 9 %1 http://www.ncbi.nlm.nih.gov/pubmed/11533660?dopt=Abstract %R 10.1038/ncb0901-809