@article {874086,
	title = {Seipin is required for converting nascent to mature lipid droplets.},
	journal = {Elife},
	volume = {5},
	year = {2016},
	month = {2016 Aug 26},
	abstract = {How proteins control the biogenesis of cellular lipid droplets (LDs) is poorly understood. Using Drosophila and human cells, we show here that seipin, an ER protein implicated in LD biology, mediates a discrete step in LD formation-the conversion of small, nascent LDs to larger, mature LDs. Seipin forms discrete and dynamic foci in the ER that interact with nascent LDs to enable their growth. In the absence of seipin, numerous small, nascent LDs accumulate near the ER and most often fail to grow. Those that do grow prematurely acquire lipid synthesis enzymes and undergo expansion, eventually leading to the giant LDs characteristic of seipin deficiency. Our studies identify a discrete step of LD formation, namely the conversion of nascent LDs to mature LDs, and define a molecular role for seipin in this process, most likely by acting at ER-LD contact sites to enable lipid transfer to nascent LDs.},
	issn = {2050-084X},
	doi = {10.7554/eLife.16582},
	author = {Wang, Huajin and Becuwe, Michel and Housden, Benjamin E and Chitraju, Chandramohan and Porras, Ashley J and Graham, Morven M and Liu, Xinran N and Thiam, Abdou Rachid and Savage, David B and Agarwal, Anil K and Garg, Abhimanyu and Olarte, Maria-Jesus and Lin, Qingqing and Fr{\"o}hlich, Florian and Hannibal-Bach, Hans Kristian and Upadhyayula, Srigokul and Perrimon, Norbert and Kirchhausen, Tomas and Ejsing, Christer S and Walther, Tobias C and Farese, Robert V}
}
