@article {843481,
	title = {Interaction between Wingless and Notch signaling pathways mediated by dishevelled.},
	journal = {Science},
	volume = {271},
	number = {5257},
	year = {1996},
	month = {1996 Mar 29},
	pages = {1826-32},
	abstract = {
	In Drosophila, the Wingless and Notch signaling pathways function in m any of the same developmental patterning events. Genetic analysis demonstrates that the dishevelled gene, which encodes a molecule previously implicated in implementation of the Winglass signal, interacts antagonistically with Notch and one of its known ligands, Delta. A direct physical interaction between Dishevelled and the Notch carboxyl terminus, distal to the cdc10/ankyrin repeats, suggests a mechanism for this interaction. It is proposed that Dishevelled, in addition to transducing the Wingless signal, blocks Notch signaling directly, thus providing a molecular mechanism for the inhibitory cross talk observed between these pathways.

},
	keywords = {Adaptor Proteins, Signal Transducing, Amino Acid Sequence, Animals, Clone Cells, Drosophila, Drosophila Proteins, Genes, Insect, Intracellular Signaling Peptides and Proteins, Membrane Proteins, Molecular Sequence Data, Mutation, Phenotype, Phosphoproteins, Proteins, Proto-Oncogene Proteins, Pupa, Receptors, Notch, Signal Transduction, Wings, Animal, Wnt1 Protein},
	issn = {0036-8075},
	author = {Axelrod, J D and Matsuno, K and Artavanis-Tsakonas, S and Perrimon, N}
}
