@article {836231,
	title = {Dual role of the fringe connection gene in both heparan sulphate and fringe-dependent signalling events.},
	journal = {Nat Cell Biol},
	volume = {3},
	number = {9},
	year = {2001},
	month = {2001 Sep},
	pages = {809-15},
	abstract = {
	The precise regulation of growth factor signalling is crucial to the molecular control of development in Drosophila. Post-translational modification of signalling molecules is one of the mechanisms that modulate developmental signalling specificity. We describe a new gene, fringe connection (frc), that encodes a nucleotide-sugar transporter that transfers UDP-glucuronic acid, UDP-N-acetylglucosamine and possibly UDP-xylose from the cytoplasm into the lumen of the endoplasmic reticulum/Golgi. Embryos with the frc mutation display defects in Wingless, Hedgehog and fibroblast growth factor signalling. Clonal analysis shows that fringe-dependent Notch signalling is disrupted in frc mutant tissue.

},
	keywords = {Amino Acid Sequence, Animals, Cytoplasm, Drosophila melanogaster, Drosophila Proteins, Endoplasmic Reticulum, Glycosyltransferases, Golgi Apparatus, Heparitin Sulfate, Humans, Molecular Sequence Data, Morphogenesis, N-Acetylglucosaminyltransferases, Phenotype, Sequence Alignment, Sequence Homology, Amino Acid, Signal Transduction, Uridine Diphosphate Glucuronic Acid, Uridine Diphosphate N-Acetylglucosamine, Uridine Diphosphate Xylose, Wings, Animal},
	issn = {1465-7392},
	doi = {10.1038/ncb0901-809},
	author = {Selva, E M and Hong, K and Baeg, G H and Beverley, S M and Turco, S J and Perrimon, N and H{\"a}cker, U}
}
