@article {836056,
	title = {Signaling role of hemocytes in Drosophila JAK/STAT-dependent response to septic injury.},
	journal = {Dev Cell},
	volume = {5},
	number = {3},
	year = {2003},
	month = {2003 Sep},
	pages = {441-50},
	abstract = {
	To characterize the features of JAK/STAT signaling in Drosophila immune response, we have identified totA as a gene that is regulated by the JAK/STAT pathway in response to septic injury. We show that septic injury triggers the hemocyte-specific expression of upd3, a gene encoding a novel Upd-like cytokine that is necessary for the JAK/STAT-dependent activation of totA in the Drosophila counterpart of the mammalian liver, the fat body. In addition, we demonstrate that totA activation also requires the NF-KB-like Relish pathway, indicating that fat body cells integrate the activity of NF-KB and JAK/STAT signaling pathways upon immune response. This study reveals that, in addition to the pattern recognition receptor-mediated NF-KB-dependent immune response, Drosophila undergoes a complex systemic response that is mediated by the production of cytokines in blood cells, a process that is similar to the acute phase response in mammals.

},
	keywords = {Adipocytes, Animals, Blotting, Northern, Bridged Compounds, Cloning, Molecular, DNA-Binding Proteins, Drosophila, Drosophila Proteins, Fat Body, Female, Gene Expression Regulation, Developmental, Hemocytes, Immunohistochemistry, In Situ Hybridization, Infection, Insect Proteins, Male, Membrane Proteins, Protein-Tyrosine Kinases, Receptors, Interleukin, Reverse Transcriptase Polymerase Chain Reaction, RNA, Messenger, Sequence Analysis, Protein, Signal Transduction, Time Factors, Trans-Activators, Transcription Factors, Transgenes},
	issn = {1534-5807},
	author = {Agaisse, Herv{\'e} and Petersen, Ulla Maja and Boutros, Michael and Mathey-Prevot, Bernard and Perrimon, Norbert}
}
