@article {834476,
	title = {Genome-wide RNAi screen for host factors required for intracellular bacterial infection.},
	journal = {Science},
	volume = {309},
	number = {5738},
	year = {2005},
	month = {2005 Aug 19},
	pages = {1248-51},
	abstract = {Most studies of host-pathogen interactions have focused on pathogen-specific virulence determinants. Here, we report a genome-wide RNA interference screen to identify host factors required for intracellular bacterial pathogenesis. Using Drosophila cells and the cytosolic pathogen Listeria monocytogenes, we identified 305 double-stranded RNAs targeting a wide range of cellular functions that altered L. monocytogenes infection. Comparison to a similar screen with Mycobacterium fortuitum, a vacuolar pathogen, identified host factors that may play a general role in intracellular pathogenesis and factors that specifically affect access to the cytosol by L. monocytogenes.},
	keywords = {Animals, Cell Cycle, Cell Line, Cytoskeleton, Cytosol, Drosophila melanogaster, Drosophila Proteins, Genes, Insect, Genome, Green Fluorescent Proteins, Listeria monocytogenes, Macrophages, Mycobacterium fortuitum, Phenotype, RNA Interference, RNA Processing, Post-Transcriptional, RNA, Double-Stranded, Signal Transduction, Vacuoles, Vesicular Transport Proteins},
	issn = {1095-9203},
	doi = {10.1126/science.1116008},
	author = {Agaisse, Herv{\'e} and Burrack, Laura S and Philips, Jennifer A and Rubin, Eric J and Perrimon, Norbert and Higgins, Darren E}
}
