@article {834471,
	title = {Drosophila RNAi screen reveals CD36 family member required for mycobacterial infection.},
	journal = {Science},
	volume = {309},
	number = {5738},
	year = {2005},
	month = {2005 Aug 19},
	pages = {1251-3},
	abstract = {
	Certain pathogens, such as Mycobacterium tuberculosis, survive within the hostile intracellular environment of a macrophage. To identify host factors required for mycobacterial entry and survival within macrophages, we performed a genomewide RNA interference screen in Drosophila macrophage-like cells, using Mycobacterium fortuitum. We identified factors required for general phagocytosis, as well as those needed specifically for mycobacterial infection. One specific factor, Peste (Pes), is a CD36 family member required for uptake of mycobacteria, but not Escherichia coli or Staphylococcus aureus. Moreover, mammalian class B scavenger receptors (SRs) conferred uptake of bacteria into nonphagocytic cells, with SR-BI and SR-BII uniquely mediating uptake of M. fortuitum, which suggests a conserved role for class B SRs in pattern recognition and innate immunity.

},
	keywords = {Animals, Antigens, CD36, Cell Line, Cytoskeleton, Drosophila melanogaster, Escherichia coli, Humans, Immunity, Innate, Lysosome-Associated Membrane Glycoproteins, Macrophages, Membrane Proteins, Mice, Mycobacterium fortuitum, Phagocytosis, Receptors, Immunologic, Receptors, Scavenger, RNA Interference, RNA, Double-Stranded, Scavenger Receptors, Class B, Sialoglycoproteins, Staphylococcus aureus, Transfection, Transport Vesicles},
	issn = {1095-9203},
	doi = {10.1126/science.1116006},
	author = {Philips, Jennifer A and Rubin, Eric J and Perrimon, Norbert}
}
