@article {834456, title = {Extrusion and death of DPP/BMP-compromised epithelial cells in the developing Drosophila wing.}, journal = {Science}, volume = {307}, number = {5716}, year = {2005}, month = {2005 Mar 18}, pages = {1785-9}, abstract = { During animal development, epithelial cell fates are specified according to spatial position by extracellular signaling pathways. Among these, the transforming growth factor beta/bone morphogenetic protein (TGF-beta/BMP) pathways are evolutionarily conserved and play crucial roles in the development and homeostasis of a wide range of multicellular tissues. Here we show that in the developing Drosophila wing imaginal epithelium, cell clones deprived of the BMP-like ligand Decapentaplegic (DPP) do not die as previously thought but rather extrude from the cell layer as viable cysts exhibiting marked abnormalities in cell shape and cytoskeletal organization. We propose that in addition to assigning cell fates, a crucial developmental function of DPP/BMP signaling is the position-specific control of epithelial architecture. }, keywords = {Actins, Alleles, Animals, Apoptosis, Body Patterning, Cell Death, Cell Shape, Clone Cells, Drosophila melanogaster, Drosophila Proteins, Epithelial Cells, Ethyl Methanesulfonate, JNK Mitogen-Activated Protein Kinases, Microtubules, Morphogenesis, Mutagens, Mutation, Phenotype, Protein-Serine-Threonine Kinases, Receptors, Cell Surface, Signal Transduction, Transforming Growth Factor beta, Wings, Animal}, issn = {1095-9203}, doi = {10.1126/science.1104751}, author = {Gibson, Matthew C and Perrimon, Norbert} }