@article {824826,
	title = {The developmental transcriptome of Drosophila melanogaster.},
	journal = {Nature},
	volume = {471},
	number = {7339},
	year = {2011},
	month = {2011 Mar 24},
	pages = {473-9},
	abstract = {Drosophila melanogaster is one of the most well studied genetic model organisms; nonetheless, its genome still contains unannotated coding and non-coding genes, transcripts, exons and RNA editing sites. Full discovery and annotation are pre-requisites for understanding how the regulation of transcription, splicing and RNA editing directs the development of this complex organism. Here we used RNA-Seq, tiling microarrays and cDNA sequencing to explore the transcriptome in 30 distinct developmental stages. We identified 111,195 new elements, including thousands of genes, coding and non-coding transcripts, exons, splicing and editing events, and inferred protein isoforms that previously eluded discovery using established experimental, prediction and conservation-based approaches. These data substantially expand the number of known transcribed elements in the Drosophila genome and provide a high-resolution view of transcriptome dynamics throughout development.},
	keywords = {Alternative Splicing, Animals, Base Sequence, Drosophila melanogaster, Drosophila Proteins, Exons, Female, Gene Expression Profiling, Gene Expression Regulation, Developmental, Genes, Insect, Genome, Insect, Male, MicroRNAs, Oligonucleotide Array Sequence Analysis, Protein Isoforms, RNA Editing, RNA, Messenger, RNA, Small Untranslated, Sequence Analysis, Sex Characteristics, Transcription, Genetic},
	issn = {1476-4687},
	doi = {10.1038/nature09715},
	author = {Graveley, Brenton R and Brooks, Angela N and Carlson, Joseph W and Duff, Michael O and Landolin, Jane M and Yang, Li and Artieri, Carlo G and van Baren, Marijke J and Boley, Nathan and Booth, Benjamin W and Brown, James B and Cherbas, Lucy and Davis, Carrie A and Dobin, Alex and Li, Renhua and Lin, Wei and Malone, John H and Mattiuzzo, Nicolas R and Miller, David and Sturgill, David and Tuch, Brian B and Zaleski, Chris and Zhang, Dayu and Blanchette, Marco and Dudoit, Sandrine and Eads, Brian and Green, Richard E and Hammonds, Ann and Jiang, Lichun and Kapranov, Phil and Langton, Laura and Perrimon, Norbert and Sandler, Jeremy E and Wan, Kenneth H and Willingham, Aarron and Zhang, Yu and Zou, Yi and Andrews, Justen and Bickel, Peter J and Brenner, Steven E and Brent, Michael R and Cherbas, Peter and Gingeras, Thomas R and Hoskins, Roger A and Kaufman, Thomas C and Oliver, Brian and Celniker, Susan E}
}
