@article {805526,
	title = {The Drosophila spitz gene encodes a putative EGF-like growth factor involved in dorsal-ventral axis formation and neurogenesis.},
	journal = {Genes Dev},
	volume = {6},
	number = {8},
	year = {1992},
	month = {1992 Aug},
	pages = {1503-17},
	abstract = {
	We describe the molecular characterization of the Drosophila gene spitz (spi), which encodes a putative 26-kD, EGF-like transmembrane protein that is structurally similar to TGF-alpha. Temporal and spatial expression patterns of spi transcripts indicate that spi is expressed throughout the embryo. Examination of mutant embryos reveals that spi is involved in a number of unrelated developmental choices, for example, dorsal-ventral axis formation, glial migration, sensory organ determination, and muscle development. We propose that spi may act as a ligand for cell-specific receptors, possibly rhomboid and/or the Drosophila EGF receptor homolog.

},
	keywords = {Amino Acid Sequence, Animals, Base Sequence, Blotting, Northern, Cloning, Molecular, Drosophila, Drosophila Proteins, Epidermal Growth Factor, Larva, Membrane Proteins, Molecular Sequence Data, Mutation, Nucleic Acid Hybridization, Recombinant Fusion Proteins},
	issn = {0890-9369},
	author = {Rutledge, B J and Zhang, K and Bier, E and Jan, Y N and Perrimon, N}
}
