@article {761736,
	title = {Comparative analysis of the transcriptome across distant species.},
	journal = {Nature},
	volume = {512},
	number = {7515},
	year = {2014},
	month = {2014 Aug 28},
	pages = {445-8},
	abstract = {The transcriptome is the readout of the genome. Identifying common features in it across distant species can reveal fundamental principles. To this end, the ENCODE and modENCODE consortia have generated large amounts of matched RNA-sequencing data for human, worm and fly. Uniform processing and comprehensive annotation of these data allow comparison across metazoan phyla, extending beyond earlier within-phylum transcriptome comparisons and revealing ancient, conserved features. Specifically, we discover co-expression modules shared across animals, many of which are enriched in developmental genes. Moreover, we use expression patterns to align the stages in worm and fly development and find a novel pairing between worm embryo and fly pupae, in addition to the embryo-to-embryo and larvae-to-larvae pairings. Furthermore, we find that the extent of non-canonical, non-coding transcription is similar in each organism, per base pair. Finally, we find in all three organisms that the gene-expression levels, both coding and non-coding, can be quantitatively predicted from chromatin features at the promoter using a {\textquoteright}universal model{\textquoteright} based on a single set of organism-independent parameters.},
	keywords = {Animals, Caenorhabditis elegans, Chromatin, Cluster Analysis, Drosophila melanogaster, Gene Expression Profiling, Gene Expression Regulation, Developmental, Histones, Humans, Larva, Models, Genetic, Molecular Sequence Annotation, Promoter Regions, Genetic, Pupa, RNA, Untranslated, Sequence Analysis, RNA, Transcriptome},
	issn = {1476-4687},
	doi = {10.1038/nature13424},
	author = {Gerstein, Mark B and Rozowsky, Joel and Yan, Koon-Kiu and Wang, Daifeng and Cheng, Chao and Brown, James B and Davis, Carrie A and Hillier, LaDeana and Sisu, Cristina and Li, Jingyi Jessica and Pei, Baikang and Harmanci, Arif O and Duff, Michael O and Djebali, Sarah and Alexander, Roger P and Alver, Burak H and Auerbach, Raymond and Bell, Kimberly and Bickel, Peter J and Boeck, Max E and Boley, Nathan P and Booth, Benjamin W and Cherbas, Lucy and Cherbas, Peter and Di, Chao and Dobin, Alex and Drenkow, Jorg and Ewing, Brent and Fang, Gang and Fastuca, Megan and Feingold, Elise A and Frankish, Adam and Gao, Guanjun and Good, Peter J and Guig{\'o}, Roderic and Hammonds, Ann and Harrow, Jen and Hoskins, Roger A and Howald, C{\'e}dric and Hu, Long and Huang, Haiyan and Hubbard, Tim J P and Huynh, Chau and Jha, Sonali and Kasper, Dionna and Kato, Masaomi and Kaufman, Thomas C and Kitchen, Robert R and Ladewig, Erik and Lagarde, Julien and Lai, Eric and Leng, Jing and Lu, Zhi and MacCoss, Michael and May, Gemma and McWhirter, Rebecca and Merrihew, Gennifer and Miller, David M and Mortazavi, Ali and Murad, Rabi and Oliver, Brian and Olson, Sara and Park, Peter J and Pazin, Michael J and Perrimon, Norbert and Pervouchine, Dmitri and Reinke, Valerie and Reymond, Alexandre and Robinson, Garrett and Samsonova, Anastasia and Saunders, Gary I and Schlesinger, Felix and Sethi, Anurag and Slack, Frank J and Spencer, William C and Stoiber, Marcus H and Strasbourger, Pnina and Tanzer, Andrea and Thompson, Owen A and Wan, Kenneth H and Wang, Guilin and Wang, Huaien and Watkins, Kathie L and Wen, Jiayu and Wen, Kejia and Xue, Chenghai and Yang, Li and Yip, Kevin and Zaleski, Chris and Zhang, Yan and Zheng, Henry and Brenner, Steven E and Graveley, Brenton R and Celniker, Susan E and Gingeras, Thomas R and Waterston, Robert}
}
