@article {760681,
	title = {Clonal analysis of the tissue specificity of recessive female-sterile mutations of Drosophila melanogaster using a dominant female-sterile mutation Fs(1)K1237.},
	journal = {Dev Biol},
	volume = {100},
	number = {2},
	year = {1983},
	month = {1983 Dec},
	pages = {365-73},
	abstract = {
	Using the newly isolated, germ line-dependent dominant female-sterile mutation Fs(1)K1237, we have characterized the germ line or somatic line dependence of 25 X-linked recessive female-sterile mutations. Since Fs(1)K1237/+ females fail to lay eggs, only germ line cells which lose Fs(1)K1237 as a result of X-ray-induced mitotic recombination are capable of producing eggs. Such recombination events will render genes on the homologous chromosome homozygous. If this chromosome carries a recessive female-sterile mutation, the fertility will be restored only if the altered function is not required in the germ line. Using this test, we have classified 25 recessive female-sterile mutations: 12 affect germ line function, 12 affect somatic line function, and one gave an ambiguous result for which an explanation is proposed. For a few of the somatic line-dependent mutants, we found that some eggs derived from germ line clones showed the same phenotype as eggs laid by females homozygous for the recessive female-sterile mutation. These results are discussed in terms of a coincident production of clones in the follicle cells.

},
	keywords = {Animals, Chromosome Mapping, Clone Cells, Drosophila melanogaster, Female, Genes, Recessive, Genetic Linkage, Genitalia, Infertility, Female, Mutation, Oogenesis, X Chromosome},
	issn = {0012-1606},
	author = {Perrimon, Norbert and Gans, Madeleine}
}
