@article {760636,
	title = {Genetic evidence that the sans fille locus is involved in Drosophila sex determination.},
	journal = {Genetics},
	volume = {120},
	number = {1},
	year = {1988},
	month = {1988 Sep},
	pages = {159-71},
	abstract = {
	Females homozygous for sans fille1621 (= fs(1)1621) have an abnormal germ line. Instead of producing eggs, the germ-line cells proliferate forming ovarian tumors or excessive numbers of nurse cells. The Sex-lethal gene product(s) regulate the branch point of the dosage compensation and sex determination pathways in the soma. The role of Sex-lethal in the germ line is not clear but the germ line of females homozygous for female sterile Sex-lethal alleles or germ-line clones of loss-of-function alleles are characterized by ovarian tumors. Females heterozygous for sans fille1621 or Sex-lethal are phenotypically wild type with respect to viability and fertility but females trans-heterozygous for sans fille1621 and Sex-lethal show ovarian tumors, somatic sexual transformations, and greatly reduced viability.

},
	keywords = {Animals, Chromosome Mapping, Crosses, Genetic, Drosophila, Female, Genes, Lethal, Genes, Regulator, Genetic Complementation Test, Genotype, Heterozygote, Homozygote, Male, Mutation, Phenotype, Sex Determination Analysis, Temperature},
	issn = {0016-6731},
	author = {Oliver, Brian and Perrimon, Norbert and Mahowald, Anthony P}
}
