@article {759956,
	title = {CKA, a novel multidomain protein, regulates the JUN N-terminal kinase signal transduction pathway in Drosophila.},
	journal = {Mol Cell Biol},
	volume = {22},
	number = {6},
	year = {2002},
	month = {2002 Mar},
	pages = {1792-803},
	abstract = {
	The Drosophila melanogaster JUN N-terminal kinase (DJNK) and DPP (decapentaplegic) signal transduction pathways coordinately regulate epithelial cell sheet movement during the process of dorsal closure in the embryo. By a genetic screen of mutations affecting dorsal closure in Drosophila, we have now identified a multidomain protein, connector of kinase to AP-1 (cka), that functions in the DJNK pathway and controls the localized expression of dpp in the leading-edge cells. We have also investigated how CKA acts. This unique molecule forms a complex with HEP (DJNKK), BSK (DJNK), DJUN, and DFOS. Complex formation activates BSK kinase, which in turn phosphorylates and activates DJUN and DFOS. These data suggest that CKA represents a novel molecule regulating AP-1 activity by organizing a molecular complex of kinases and transcription factors, thus coordinating the spatial-temporal expression of AP-1-regulated genes.

},
	keywords = {3T3 Cells, Adaptor Proteins, Signal Transducing, Animals, Carrier Proteins, Drosophila melanogaster, Drosophila Proteins, Insect Proteins, JNK Mitogen-Activated Protein Kinases, Macromolecular Substances, Mice, Mitogen-Activated Protein Kinase Kinases, Mitogen-Activated Protein Kinases, Molecular Sequence Data, Phosphorylation, Protein Structure, Tertiary, Protein-Tyrosine Kinases, Sequence Homology, Amino Acid, Signal Transduction, Transcription Factor AP-1, Transcription Factors, Transcription, Genetic, Transfection},
	issn = {0270-7306},
	author = {Chen, Hua-Wei and Marinissen, Maria Julia and Oh, Su-Wan and Chen, Xiu and Melnick, Michael and Perrimon, Norbert and Gutkind, J Silvio and Hou, Steven X}
}
