@article {759936,
	title = {Polarity determination in the Drosophila eye: a novel role for unpaired and JAK/STAT signaling.},
	journal = {Genes Dev},
	volume = {13},
	number = {10},
	year = {1999},
	month = {1999 May 15},
	pages = {1342-53},
	abstract = {
	The JAK/STAT signaling pathway is required for many processes including cytokine signaling, hematopoiesis, gliagenesis, and Drosophila segmentation. In this report we present evidence demonstrating that the JAK/STAT pathway is also central to the establishment of planar polarity during Drosophila eye development. We show that a localized source of the pathway ligand, Unpaired, is present at the midline of the developing eye, which is capable of activating the JAK/STAT pathway over long distances. A gradient of JAK/STAT activity across the DV axis of the eye regulates ommatidial polarity via an unidentified second signal. Additionally, localized Unpaired influences the position of the equator via repression of mirror.

},
	keywords = {Animals, Body Patterning, DNA-Binding Proteins, Drosophila, Drosophila Proteins, Eye, Glycoproteins, Janus Kinase 1, Janus Kinases, Models, Biological, Protein-Tyrosine Kinases, Signal Transduction, STAT Transcription Factors, STAT1 Transcription Factor, Trans-Activators, Transcription Factors},
	issn = {0890-9369},
	author = {Zeidler, M P and Perrimon, N and Strutt, D I}
}
