@article {759916,
	title = {Ecdysone signaling at metamorphosis triggers apoptosis of Drosophila abdominal muscles.},
	journal = {Dev Biol},
	volume = {383},
	number = {2},
	year = {2013},
	month = {2013 Nov 15},
	pages = {275-84},
	abstract = {One of the most dramatic examples of programmed cell death occurs during Drosophila metamorphosis, when most of the larval tissues are destroyed in a process termed histolysis. Much of our understanding of this process comes from analyses of salivary gland and midgut cell death. In contrast, relatively little is known about the degradation of the larval musculature. Here, we analyze the programmed destruction of the abdominal dorsal exterior oblique muscle (DEOM) which occurs during the first 24h of metamorphosis. We find that ecdysone signaling through Ecdysone receptor isoform B1 is required cell autonomously for the muscle death. Furthermore, we show that the orphan nuclear receptor FTZ-F1, opposed by another nuclear receptor, HR39, plays a critical role in the timing of DEOM histolysis. Finally, we show that unlike the histolysis of salivary gland and midgut, abdominal muscle death occurs by apoptosis, and does not require autophagy. Thus, there is no set rule as to the role of autophagy and apoptosis during Drosophila histolysis.},
	keywords = {Abdomen, Abdominal Muscles, Animals, Apoptosis, Autophagy, Caspases, Drosophila melanogaster, Drosophila Proteins, Ecdysone, Epistasis, Genetic, Larva, Metamorphosis, Biological, Muscles, Sarcomeres, Signal Transduction, Time Factors},
	issn = {1095-564X},
	doi = {10.1016/j.ydbio.2013.08.029},
	author = {Zirin, Jonathan and Cheng, Daojun and Dhanyasi, Nagaraju and Cho, Julio and Dura, Jean-Maurice and Vijayraghavan, Krishnaswamy and Perrimon, Norbert}
}
