@article {1518547,
	title = {A  model of oral peptide therapeutics for adult intestinal stem cell tumors},
	journal = {Dis Model Mech},
	volume = {13},
	number = {7},
	year = {2020},
	month = {2020 07 23},
	abstract = {Peptide therapeutics, unlike small-molecule drugs, display crucial advantages of target specificity and the ability to block large interacting interfaces, such as those of transcription factors. The transcription co-factor of the Hippo pathway, YAP/Yorkie (Yki), has been implicated in many cancers, and is dependent on its interaction with the DNA-binding TEAD/Sd proteins via a large Ω-loop. In addition, the mammalian vestigial-like (VGLL) proteins, specifically their TONDU domain, competitively inhibit YAP-TEAD interaction, resulting in arrest of tumor growth. Here, we show that overexpression of the TONDU peptide or its oral uptake leads to suppression of Yki-driven intestinal stem cell tumors in the adult  midgut. In addition, comparative proteomic analyses of peptide-treated and untreated tumors, together with chromatin immunoprecipitation analysis, reveal that integrin pathway members are part of the Yki-oncogenic network. Collectively, our findings establish  as a reliable  platform to screen for cancer oral therapeutic peptides and reveal a tumor suppressive role for integrins in Yki-driven tumors.This article has an associated First Person interview with the first author of the paper.},
	issn = {1754-8411},
	doi = {10.1242/dmm.044420},
	author = {Bajpai, Anjali and Quazi, Taushif Ahmad and Tang, Hong-Wen and Manzar, Nishat and Singh, Virender and Thakur, Ashwani and Ateeq, Bushra and Perrimon, Norbert and Sinha, Pradip}
}
