@article {1509201,
	title = {A single-cell survey of  blood},
	journal = {Elife},
	volume = {9},
	year = {2020},
	month = {2020 05 12},
	abstract = { blood cells, called hemocytes, are classified into plasmatocytes, crystal cells, and lamellocytes based on the expression of a few marker genes and cell morphologies, which are inadequate to classify the complete hemocyte repertoire. Here, we used single-cell RNA sequencing (scRNA-seq) to map hemocytes across different inflammatory conditions in larvae. We resolved plasmatocytes into different states based on the expression of genes involved in cell cycle, antimicrobial response, and metabolism together with the identification of intermediate states. Further, we discovered rare subsets within crystal cells and lamellocytes that express fibroblast growth factor (FGF) ligand  and receptor , respectively. We demonstrate that these FGF components are required for mediating effective immune responses against parasitoid wasp eggs, highlighting a novel role for FGF signaling in inter-hemocyte crosstalk. Our scRNA-seq analysis reveals the diversity of hemocytes and provides a rich resource of gene expression profiles for a systems-level understanding of their functions.},
	issn = {2050-084X},
	doi = {10.7554/eLife.54818},
	author = {Tattikota, Sudhir Gopal and Cho, Bumsik and Liu, Yifang and Hu, Yanhui and Barrera, Victor and Steinbaugh, Michael J and Yoon, Sang-Ho and Comjean, Aram and Li, Fangge and Dervis, Franz and Hung, Ruei-Jiun and Nam, Jin-Wu and Ho Sui, Shannan and Shim, Jiwon and Perrimon, Norbert}
}
