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##  645 results 

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### 2026

Han M, Xia B, Kim AR, Filine E, Stoneburner E, Miao T, Liu Y, Zirin J, Perrimon N. [Phage display-mediated immuno-PCR to detect low-abundance secreted proteins in .](https://www.pnas.org/doi/10.1073/pnas.2531777123?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed)

Proceedings of the National Academy of Sciences of the United States of America. 2026;123(15):e2531777123. PMID: 41941621





 

 

Han M, Xia B, Kim AR, Filine E, Stoneburner E, Miao T, Liu Y, Zirin J, Perrimon N. [Phage display-mediated immuno-PCR to detect low-abundance secreted proteins in .](https://www.pnas.org/doi/10.1073/pnas.2531777123?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed)

Proceedings of the National Academy of Sciences of the United States of America. 2026;123(15):e2531777123. PMID: 41941621





 

 

 

- add\_circle do\_not\_disturb\_on Abstract
- [ picture\_as\_pdfhan-et-al-2026-phage-disp...](/sites/g/files/omnuum4036/files/2026-04/han-et-al-2026-phage-display-mediated-immuno-pcr-to-detect-low-abundance-secreted-proteins-in-drosophila.pdf)
 
Circulating hormones, that mediate communications across organs to maintain physiological balance, are commonly detected and quantified using enzyme-linked immunosorbent assays (ELISAs). However, while ELISA is well suited for organisms where sample blood...



 

 

- [ picture\_as\_pdfhan-et-al-2026-phage-disp...](/sites/g/files/omnuum4036/files/2026-04/han-et-al-2026-phage-display-mediated-immuno-pcr-to-detect-low-abundance-secreted-proteins-in-drosophila.pdf)
 
 

Miao T, Liu Y, Qadiri M, Dasseux A, Asara JM, Hu Y, Sun X, Pliego-Alcántara LDC, Dibble CC, Perrimon N. [Renal coenzyme A (CoA) production from VB5 fuels stem cell proliferation and tumor growth.](https://www.nature.com/articles/s41467-026-71716-1)

Nature communications. 2026; PMID: 42000723





 

 

Miao T, Liu Y, Qadiri M, Dasseux A, Asara JM, Hu Y, Sun X, Pliego-Alcántara LDC, Dibble CC, Perrimon N. [Renal coenzyme A (CoA) production from VB5 fuels stem cell proliferation and tumor growth.](https://www.nature.com/articles/s41467-026-71716-1)

Nature communications. 2026; PMID: 42000723





 

 

 

- add\_circle do\_not\_disturb\_on Abstract
 
Coenzyme A (CoA), derived from Vitamin B5 (VB5; also called pantothenate), is essential for lipid metabolism, energy production, and cell proliferation. While the intracellular functions of CoA are well-characterized, much less is known about its tissue...



 

 

 

Bosch JA, Beltran PMJ, Cavers C, LaGraff JT, Melanson R, Singh A, Chen W, Hu Y, Tattikota SG, Liu Y, Hashmi Y, Asara JM, Branon T, Ting AY, Carr SA, Perrimon N. [Multi-omic mapping of Drosophila protein secretomes reveals tissue-specific origins and inter-organ trafficking.](https://www.nature.com/articles/s41467-026-71763-8)

Nature communications. 2026; PMID: 42009678





 

 

Bosch JA, Beltran PMJ, Cavers C, LaGraff JT, Melanson R, Singh A, Chen W, Hu Y, Tattikota SG, Liu Y, Hashmi Y, Asara JM, Branon T, Ting AY, Carr SA, Perrimon N. [Multi-omic mapping of Drosophila protein secretomes reveals tissue-specific origins and inter-organ trafficking.](https://www.nature.com/articles/s41467-026-71763-8)

Nature communications. 2026; PMID: 42009678





 

 

 

- add\_circle do\_not\_disturb\_on Abstract
 
Secreted proteins regulate many aspects of animal biology and are attractive targets for biomarkers and therapeutics. However, comprehensively identifying the "secretome", along with their tissues of origin, remains extremely challenging. To address this...



 

 

 

Xu Y, Stubbendieck RM, Viswanatha R, Krč A, Baik LS, Suh WS, Hu Y, Wang H, Yin L, Mameli E, van der Meij A, Carlson JR, Doxey AC, Stenmark P, Perrimon N, Currie CR, Dong M. [Streptomyces produce a diphtheria toxin-like exotoxin that targets insects.](https://www.nature.com/articles/s41564-026-02315-5)

Nature microbiology. 2026; PMID: 42062574





 

 

Xu Y, Stubbendieck RM, Viswanatha R, Krč A, Baik LS, Suh WS, Hu Y, Wang H, Yin L, Mameli E, van der Meij A, Carlson JR, Doxey AC, Stenmark P, Perrimon N, Currie CR, Dong M. [Streptomyces produce a diphtheria toxin-like exotoxin that targets insects.](https://www.nature.com/articles/s41564-026-02315-5)

Nature microbiology. 2026; PMID: 42062574





 

 

 

- add\_circle do\_not\_disturb\_on Abstract
 
Streptomyces and insects engage in complex interactions shaped by millions of years of evolution. While many beneficial relationships are well recognized, it remains unknown whether Streptomyces produce virulence factors targeting insects specifically...



 

 

 

Petsakou A, Filine E, Li M, Chen Y, Zheng A, Perrimon N. [Tumor-induced orexigenic imbalance lowers protein appetite and drives early organ wasting symptoms.](https://www.nature.com/articles/s41467-026-70074-2)

Nature communications. 2026;17(1). PMCID: PMC13086994





 

 

Petsakou A, Filine E, Li M, Chen Y, Zheng A, Perrimon N. [Tumor-induced orexigenic imbalance lowers protein appetite and drives early organ wasting symptoms.](https://www.nature.com/articles/s41467-026-70074-2)

Nature communications. 2026;17(1). PMCID: PMC13086994





 

 

 

- add\_circle do\_not\_disturb\_on Abstract
 
Cancer cachexia (CC) is characterized by organ wasting and ensuing involuntary weight loss. Despite advances, underlying mechanisms initiating CC remain unclear, including early symptoms like anorexia. Here, we use a fly gut-tumor model with a precise...



 

 

 

Huang K, Perrimon N. [Metabolic command centers in Drosophila: how the fat body and oenocytes orchestrate immunity, reproduction, and aging.](/publication/metabolic-command-centers-drosophila-how-fat-body-and-oenocytes-orchestrate-immunity)

Current opinion in insect science. 2026;73:101459. PMID: 41218693





 

 

Huang K, Perrimon N. [Metabolic command centers in Drosophila: how the fat body and oenocytes orchestrate immunity, reproduction, and aging.](/publication/metabolic-command-centers-drosophila-how-fat-body-and-oenocytes-orchestrate-immunity)

Current opinion in insect science. 2026;73:101459. PMID: 41218693





 

 

 

- add\_circle do\_not\_disturb\_on Abstract
- [ picture\_as\_pdfMetabolic command centers...](/sites/g/files/omnuum4036/files/2026-02/Metabolic%20command%20centers%20in%20Drosophila-%20how%20the%20fat%20body%20and%20oenocytes%20orchestrate%20immunity%2C%20reproduction%2C%20and%20aging.pdf)
 
Energy storage and mobilization are fundamental to physiology and survival, yet their dysregulation drives obesity, diabetes, cancer, and age-related diseases. Drosophila melanogaster offers a tractable model for dissecting these pathways because its...



 

 

- [ picture\_as\_pdfMetabolic command centers...](/sites/g/files/omnuum4036/files/2026-02/Metabolic%20command%20centers%20in%20Drosophila-%20how%20the%20fat%20body%20and%20oenocytes%20orchestrate%20immunity%2C%20reproduction%2C%20and%20aging.pdf)
 
 

Lane EA, Petsakou A, Liu Y, Chen W, Qadiri M, Hu Y, Perrimon N. [Cholinergic signaling modulates intestinal pathophysiology in a Drosophila model of cystic fibrosis.](https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1012048)

PLoS genetics. 2026;22(2):e1012048. PMCID: PMC12923121





 

 

Lane EA, Petsakou A, Liu Y, Chen W, Qadiri M, Hu Y, Perrimon N. [Cholinergic signaling modulates intestinal pathophysiology in a Drosophila model of cystic fibrosis.](https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1012048)

PLoS genetics. 2026;22(2):e1012048. PMCID: PMC12923121





 

 

 

- add\_circle do\_not\_disturb\_on Abstract
 
Cystic fibrosis (CF) is a monogenic genetic disease caused by mutations in the Cystic Fibrosis Transmembrane conductance Regulator (CFTR) chloride/bicarbonate channel, which is expressed in certain epithelial cells. Current therapies focus on restoring...



 

 

 

Ewen-Campen B, Chen W, Tattikota SG, Liu Y, Hu Y, Perrimon N. [The Drosophila proventriculus lacks stem cells but compensates for age-related cell loss via endoreplication-mediated cell growth.](https://www.nature.com/articles/s41467-026-68876-5)

Nature communications. 2026; PMID: 41593082





 

 

Ewen-Campen B, Chen W, Tattikota SG, Liu Y, Hu Y, Perrimon N. [The Drosophila proventriculus lacks stem cells but compensates for age-related cell loss via endoreplication-mediated cell growth.](https://www.nature.com/articles/s41467-026-68876-5)

Nature communications. 2026; PMID: 41593082





 

 

 

- add\_circle do\_not\_disturb\_on Abstract
 
The Drosophila proventriculus is a bulb-shaped structure at the juncture of the foregut and the midgut, which plays important roles in ingestion, peritrophic membrane synthesis, and the immune response to oral pathogens. A previous study identified a...



 

 

 

Moon SJ, Hu Y, Dzieciatkowska M, Kim AR, Asara JM, D’Alessandro A, Perrimon N. [Modeling tissue-specific Drosophila metabolism identifies high sugar diet-induced metabolic dysregulation in muscle at reaction and pathway levels.](https://www.nature.com/articles/s41467-026-68395-3)

Nature communications. 2026; PMID: 41549107





 

 

Moon SJ, Hu Y, Dzieciatkowska M, Kim AR, Asara JM, D’Alessandro A, Perrimon N. [Modeling tissue-specific Drosophila metabolism identifies high sugar diet-induced metabolic dysregulation in muscle at reaction and pathway levels.](https://www.nature.com/articles/s41467-026-68395-3)

Nature communications. 2026; PMID: 41549107





 

 

 

- add\_circle do\_not\_disturb\_on Abstract
 
Individual tissues perform highly specialized metabolic functions to maintain whole-body metabolic homeostasis. Although Drosophila serves as a powerful model for studying human metabolic diseases, modeling tissue-specific metabolism has been limited in...



 

 

 

Lee MK, Kim SM, Lee S, Yang JH, Choi CR, Miao T, Kim JS, Perrimon N, Kang YP, Rhee HW. [Endogenous nucleophilic scavengers of reactive acyl-species neutralize carbon stress](https://www.biorxiv.org/content/10.64898/2026.04.06.716549v1).

BioRxiv. 2026;





 

 

Lee MK, Kim SM, Lee S, Yang JH, Choi CR, Miao T, Kim JS, Perrimon N, Kang YP, Rhee HW. [Endogenous nucleophilic scavengers of reactive acyl-species neutralize carbon stress](https://www.biorxiv.org/content/10.64898/2026.04.06.716549v1).

BioRxiv. 2026;





 

 

 

- add\_circle do\_not\_disturb\_on Abstract
- [ picture\_as\_pdfEndogenous nucleophilic.p...](/sites/g/files/omnuum4036/files/2026-04/Endogenous%20nucleophilic.pdf)
 
Aberrant protein acylation by reactive acyl species (RAS)—termed carbon stress—is a major driver of aging and metabolic disease. While enzymatic deacylases such as sirtuins counteract aberrant acylation, whether endogenous metabolites can directly...



 

 

- [ picture\_as\_pdfEndogenous nucleophilic.p...](/sites/g/files/omnuum4036/files/2026-04/Endogenous%20nucleophilic.pdf)
 
 

 



### 2025

Madrigal P, Thanki AS, Fexova S, Yu ID, Chatzigeorgiou A, Zucchi I, Calles JCM, Vilmovsky L, Khen A, Zhao L, Erdos K, Kurri SR, Selvakumar S, Kumbham U, Prakash A, Wang S, Green A, Ribas CE, Sweeney B, Alegbe T, Suveges D, Hemrom A, Gutierrez DEG, Insua S, Jeffryes M, Pearce M, Basutkar P, Kaforou M, Cunnington A, Levin M, Kumari S, Ware D, Goutte-Gattat D, Röper K, Brown NH, Hu Y, Perrimon N, Papatheodorou I, Brazma A, Hermjakob H, Harrison M, Ocaña D, Ochoa D, McDonagh EM, Bateman A, Keane T, Vizcaíno JA, Ernst C. [Expression Atlas in 2026: enabling FAIR and open expression data through community collaboration and integration.](https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkaf1238/8376685?rss=1)

Nucleic acids research. 2025; PMID: 41370097





 

 

Madrigal P, Thanki AS, Fexova S, Yu ID, Chatzigeorgiou A, Zucchi I, Calles JCM, Vilmovsky L, Khen A, Zhao L, Erdos K, Kurri SR, Selvakumar S, Kumbham U, Prakash A, Wang S, Green A, Ribas CE, Sweeney B, Alegbe T, Suveges D, Hemrom A, Gutierrez DEG, Insua S, Jeffryes M, Pearce M, Basutkar P, Kaforou M, Cunnington A, Levin M, Kumari S, Ware D, Goutte-Gattat D, Röper K, Brown NH, Hu Y, Perrimon N, Papatheodorou I, Brazma A, Hermjakob H, Harrison M, Ocaña D, Ochoa D, McDonagh EM, Bateman A, Keane T, Vizcaíno JA, Ernst C. [Expression Atlas in 2026: enabling FAIR and open expression data through community collaboration and integration.](https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkaf1238/8376685?rss=1)

Nucleic acids research. 2025; PMID: 41370097





 

 

 

- add\_circle do\_not\_disturb\_on Abstract
- [ picture\_as\_pdfExpression Atlas in 2026\_...](/sites/g/files/omnuum4036/files/2025-12/Expression%20Atlas%20in%202026_%20enabling%20FAIR%20and%20open%20expression%20data%20through%20community%20collaboration%20and%20integration.pdf)
 
Expression Atlas (<https://www.ebi.ac.uk/gxa/home>) is EMBL-EBI's comprehensive knowledgebase for gene and protein expression across tissues, cell types, conditions, and multiple species. Since our last update, Expression Atlas has expanded substantially in...



 

 

- [ picture\_as\_pdfExpression Atlas in 2026\_...](/sites/g/files/omnuum4036/files/2025-12/Expression%20Atlas%20in%202026_%20enabling%20FAIR%20and%20open%20expression%20data%20through%20community%20collaboration%20and%20integration.pdf)
 
 

Lin J, Deng Q, Gao Y, Tan YS, Zhong Z, Tan LKA, Tan BOP, Virshup DM, Bosch JA, Perrimon N, Wang H. [Microproteins Simba1 and Simba2 activate Wingless signaling during the reactivation of neural stem cells in Drosophila.](https://www.nature.com/articles/s41467-025-66727-3)

Nature communications. 2025;16(1):11651. PMCID: PMC12749969





 

 

Lin J, Deng Q, Gao Y, Tan YS, Zhong Z, Tan LKA, Tan BOP, Virshup DM, Bosch JA, Perrimon N, Wang H. [Microproteins Simba1 and Simba2 activate Wingless signaling during the reactivation of neural stem cells in Drosophila.](https://www.nature.com/articles/s41467-025-66727-3)

Nature communications. 2025;16(1):11651. PMCID: PMC12749969





 

 

 

- add\_circle do\_not\_disturb\_on Abstract
 
The ability of neural stem cells (NSCs) to switch between quiescent and proliferative states is fundamental for adult neurogenesis and regeneration. Microproteins or short open reading frame (sORF)-encoded peptides (SEPs), are highly abundant yet largely...



 

 

 

 



 

 

 

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